AF/LE Purified Anti-Mouse CD366/Tim-3 Antibody[RMT3-23] (E-AB-F11920)
![AF/LE Purified Anti-Mouse CD366/Tim-3 Antibody[RMT3-23] - 1](http://file.elabscience.com/assets/images/loading.png)
For research use only.
Conjugation: None (AF/LE)
APC FITC None (AF/LE) PE Unconjugated Show More
| Verified Samples | Verified Samples in FCM: HEK293T cells transfected with pcDNA3.1 plasmid encoding Mouse CD366 gene |
| Dilution | FCM 2 μg/mL(0.5×106-1×106 cells) |
| Isotype | Rat IgG2a, κ |
| Host | Rat |
| Reactivity | Mouse |
| Applications | FCM |
| Clonality | Monoclonal |
| Immunogen | Recombinant Mouse CD366 protein |
| Abbre | CD366/Tim-3 |
| Synonyms | TIM-, Tim3, TIM-3, Timd, Timd3, T-cell membrane protein, T-cell immunoglobulin mucin receptor, T-cell immunoglobulin and mucin domain-containing protein, Tim, TIM-, Tim3, Timd, TIM-3, Timd3, HAVcr-2, Hepatitis A virus cellular receptor 2 homolog, T-cell immunoglobulin and mucin domain-containing protein 3, T-cell immunoglobulin mucin receptor 3, T-cell membrane protein 3, TIMD-3, Havcr2, T cell immunoglobulin and mucin domain containing 3 protein, hepatitis virus cellular receptor 2 |
| Swissprot | |
| Cellular Localization | Membrane |
| Concentration | ≥ 1 mg/mL |
| Buffer | Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method. |
| Purification Method | >98%, Protein A/G purified |
| Research Areas | Immunology, Inhibitory Molecules |
| Clone | RMT3-23 |
| Conjugation | None (AF/LE) |
| Storage | Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions. |
| Shipping | Ice bag |
| background | CD366 (Tim-3) is a transmembrane protein also known as T cell immunoglobulin and mucin domain containing protein-3. Tim-3 is expressed at high levels on activated T cells (preferentially on Th1 cells, monocytes/macrophages, and dendritic cells). Tim-3 has also been shown to exist as a soluble protein. Cells expressing Tim-3 are present at high levels in the CNS of animals at the onset of experimental autoimmune encephalomyelitis (EAE), a disease mediated by lymphocytes secreting Th1-like cytokines. Tim-3 has been proposed to inhibit Th1-mediated immune responses and promote immunological tolerance. |
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